Neutral-lipid storage disease: a new disorder of lipid metabolism.
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چکیده
منابع مشابه
Neutral lipid storage disease: a genetic disorder with abnormalities in the regulation of phospholipid metabolism.
Neutral lipid storage disease (NLSD) is an autosomal recessive disorder characterized by the presence of numerous lipid droplets in virtually all tissues examined. The increased cellular triacylglycerol content results from defective recycling of triacylglycerol-derived diacylglycerol to phospholipids (Igal, R. A. and R. A. Coleman. 1996. J. Biol. Chem. 271: 16644-16651). In order to determine ...
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The morphological changes in a patient with a generalized storage disease characterized by the intracellular deposition of neutral lipid are described. There is widespread accumulation of lipid in the cytoplasm of many cells and in occasional nuclei. Diagnosis may be facilitated by the recognition of clear vacuoles in the cytoplasm of granulocytes in blood films. In jejunal biopsies vacuolation...
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IN 1954 Sawitsky, Hyman and Hyma& described a lipid storage disorder in two young adults characterized by the presence in the bone marrow smears of large histiocytes with a distinctive blue staining granular cytoplasm. Subsequently, three additional cases have been reported and in this article a sixth case is presented along with a discussion of various aspects of the disorder.24 CASE REI'oRT T...
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ژورنال
عنوان ژورنال: BMJ
سال: 1975
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5957.553